Additionally, the museum devotes 4 of its rooms to items used in the daily lives of the early ranchers and homesteaders, those who later beat the double burden of the Dust bowl and the Depression, and those who witnessed the emergence of the modern Panhandle. Some of the items exhibited include antique quilts, horse drawn hearse and freight wagons, and a large barbed wire collection.

A large 5th room displays chipped stone tools, grinding stones, pottery, and other items used in the more ancient lifeways of Native Americans in the region, including an unusually extensive collection of Plains "arrowheads," a catlinite "peace pipe," and fine examples of beadwork and porcupine quillwork.

A 6th room is devoted to exhibits of paleontological and geological items, including dinosaur footprints and natural casts from the Kenton vicinity.

An adjacent 7th room examines the history, economy, and ecology of the area, presented through a ten panel exhibit. An 8th room displays art from the Museum's collection, and traveling exhibits.